Research and Test Reactor Licensing Branch
The United States does not produce a medical isotope used domestically in millions of diagnostic procedures each year. We’re talking about technicium-99m, or Tc‑99m — which has been called the world’s most important medical isotope.
Tc-99m is created from another radioisotope, molybdenum-99 (Mo-99), which, in some cases, is produced using highly enriched uranium. A supply shortage that delayed patient treatments several years ago, coupled with the desire to reduce proliferation risks, prompted the world community to find better ways of securing the future supply of this isotope.
In 2012, Congress passed the American Medical Isotope Production Act to support private U.S. efforts to develop non-HEU methods for medical isotope production and begin phasing out the export of HEU. The National Nuclear Security Administration has been promoting domestic Mo‑99 production using different technologies through formal cooperative agreements with commercial partners.
These partners and several other companies have said they are interested in producing Mo‑99 in the U.S. They have proposed using several different technologies, ranging from non-power reactors to accelerator-driven, subcritical solution tanks. To support the transition to new technologies, the NRC is prepared to receive and review applications for construction permits, operating licenses, and materials licenses for new facilities, as well as license amendments for existing non-power reactors.
In fact, we are now reviewing two construction permit applications and a license amendment request. We licensed a small-scale technology demonstration project earlier this year.
Companies, facilities, and technicians involved in producing and administering Tc-99m to patients may also need to be licensed by either the NRC or an Agreement State. (There are 37 Agreement States, which have formal agreements with the NRC allowing them to regulate certain nuclear materials, including medical isotopes.)
For more information on the role of the NRC and other agencies in regulating the use and production of medical isotopes and other nuclear materials, visit the NRC webpage.
Kara Mattioli also contributed to this post.
This is an update to the original blog post, which originally ran in October 2013